Alpha Lipoic Acid, Inositol and Metformin proven benefit in PCOS and weight loss.

I featured this supplement about a year ago when doing a series on detoxification support for the body.


I want to now look at how ALA helps in Poly Cystic Ovarian Syndrome (PCOS), in combination with inositol and metformin (prescribed medication).

Of particular relevance to women with PCOS, ALA has been shown to greatly increase insulin sensitivity.  It has been proven to greatly increase the rate of glucose transportation from the blood into the cells where it can provide energy to the muscles and brain versus being turning into fatty acids and stored in the fat cells (making them bigger – Oh, no! ).

Fact:  Inositol is also known as B8.


One study with PCOS subjects showed that the addition of inositol and alpha lipoic acid to metformin achieved better results in lowering weight, HOMA (homeostatic model assessment for quantifying insulin resistance), and testosterone than a higher dose of metformin alone. *  Those taking the combination almost doubled their  % decrease in BMI.

*Capasso I, Esposito E, Maurea N, Montella M, Crispo A, De Laurentiis M. Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. Trials. 2013 Aug 28;14:273. doi: 10.1186/1745-6215-14-273. PubMed PMID: 23981814; PubMed Central PMCID: PMC3765513

Some natural food sources of alpha lipoic acid:  Beets, Red Meat, Spinach, Peas, Carrots, Brussel Sprouts, Tomatoes and Broccoli.



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